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In the second study, parameters associated with bone resorption, namely, urinary NTX and deoxypyridinoline and serum TRACP5b were assessed in all subjects as well as bone formation parameters including serum osteocalcin, uncarboxylated osteocalcin (ucOC), total type 1 procollagen-N-propeptide (P1NP), and bone specific alkaline phosphatase (BAP), as were pentosidine, homocystein, intact parathyroid hormone (PTH), 25(OH)VitD, estradiol (E2), and cotinine levels

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Some of the enhanced features include: Guilloche Security Design, a feature that includes sophisticated techniques to embed a variety of customized security patterning into the credential, using non-commercial software developed specifically for high security documents (banknotes, passports, ID cards, etc)

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Tables 1,2,3,4 summarize the findings of the included studies, and Supplementary Tables 14 summarize the patient characteristics of the included studies