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The hazard ratio was slightly reduced at 40 cigarettes per day compared with 20 cigarettes per day

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For the analysis, 21-1 mediation models with random intercepts and fixed slopes were used [35]

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Thatcher TH, McHugh NA, Egan RW, Chapman RW, Hey JA, Turner CK, Redonnet MR, Seweryniak KE, Sime PJ, Phipps RP: Role of CXCR2 in cigarette smoke-induced lung inflammation

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