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Taken together, the data suggests that there is a vicious cycle of epithelial cell injury and immune activation, which in conjunction with increased susceptibility and abnormal repair mechanisms promote an abnormal airway epithelium in asthma ( 5.3 Epithelium-immune cell crosstalk in asthma In the asthmatic airway, alarmin and chemokine release induced cytokine activation is a well-recognised disease driving mechanism

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April 2018

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