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Its original vision statement was to enhance natural tobacco components that may have potential to either reduce or mitigate the biological activity of tobacco-burning cigarettes.43 This statement was later amended as follows: to provide smokers with products which contain biological activity mitigants.42 Biological activities targeted included reducing nitrosamine levels, nitric oxide levels, carbonyl groups, Ames activity (a measure of mutagenic and carcinogenic potential), ciliostatic and cytotoxic response, and possibly free radical concentrations.44 Numerous RJ Reynolds documents showed that the company considered adding mitigants, such as beta-carotene, to cigarettes.42 , 47 56 Mitigants were defined as antioxidants and other compounds for free radical reduction (i.e., reduction of the concentration of free radicals)57 , 58

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[9] In Australia in 1974, the mass hysteria was such that calls were made to have him deported from the country, especially after the madness at his 33,000-person audience concert at Melbourne Cricket Ground

Symptoms also include chest pain, fever and gastrointestinal issues

[4] History [edit] 1888 to 1991 [edit] The company's roots date back to 1888, when the first generation of the Karelia family established itself as a small tobacco business in Kalamata, Greece