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Investigations for a very short time period in canine models and long-term cannulated mice exposed to concentrated air particles showed that hypertension was produced and that there was an indication of central sympathetic activation of the neuron system, presumably induced by neuro-inflammation in relation to the disclosure of PM 2.5 (190, 191)

Were talking about cardiovascular issues, respiratory problems, and yes, a higher likelihood of serious outcomes including disease that can lead to death

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4 Examples of limited edition and themed packaging in the UK included images of motor car racing on packs of Marlboro in 2005, 7 Camel Art packs featured an eye-catching art-deco design attempting to emphasise the style and quality of the brand in 2006, a series of 'Cityscapes' themed designs on Sovereign packs in 2009, 31 and a special edition Lambert & Butler holographic pack to mark 10 years as one of the leading cigarette brands in the UK