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Some research has found that nicotine directly modulates the sebaceous gland in ways that increase sebum output and alter its composition contributing to both comedone formation and the oily surface texture associated with smoker's skin

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Frequency distribution, chemical class, and hazard classification of the 155 detected target analyte flavor chemicals The frequency with which each of the 155 detected target analyte flavor chemicals appeared in refill fluids is shown in Supplemental Table 1, Fig