Given the importance of biofilm formation for adhesion in the oral cavity [70], and the fact that cigarette smoke increased biofilm formation by specific bacteria and promoted colonization [34], it would be reasonable to suspect that oral microbiome might be the missed connectivity between smoking and infective endocarditis
And one of the ones that we do see exposures to, and sometimes in the pediatric population, are going to be a class of medicines called sulphonylureas
Polansky J, Driscoll D, and Glantz S
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[7] John Timbs' Curiosities of London (1867) records: Near the north-east corner of the Queen's Warehouse, a guide-post, inscribed 'To the Kiln', directs you to 'the Queen's Pipe', or chimney of the furnace
