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Therefore, the single perturbation strength ( PS s ) of K m_ST , when it is perturbed from the nominal value 0.5 (Supplementary Table S2) to 1.5, is calculated as follows: In this case, P ss under single perturbation is 0.0721, which is decreased by 91.8% (0.08 fold) from P ss without any perturbation (i.e., 0.8781)

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