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Strengths and limitations Strengths of this study include a large sample size (informed by an a priori power calculation), its double-blind, randomized, double-placebo-controlled, crossover design, and use of well-validated tasks

Ion Process

Smoker lips show concentrated patches of excess melanin on the lower lip and lip border, often with a grayish tone from reduced circulation

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Duration of HTP use was classified as: 1, 2, and 3 years