where did tobacco originate from History of Tobacco | The Canadian Encyclopedia

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This exercise yielded 194 statistically significant changes (compared to the 26 reported in PM's published paper, Text S1,Table S-3), suggesting that a better powered study would have detected a much broader range of biological effects associated with the additives than identified in PM's published paper [18], suggesting that it substantially underestimates the toxic potential of cigarette smoke and additives