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Here, we examined the potential mutual causality of smoking and brain development with a large longitudinal, community-based sample of adolescents

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4 Unique vulnerabilities of teens and young adults 4.1 The developing adolescent brain and cardiovascular system Adolescence is a critical neurodevelopmental period characterized by significant remodeling of brain circuits, particularly those involving the prefrontal cortex and limbic system, which govern executive function, reward processing, and emotional regulation

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