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These samples indicated a median daily exposure of 56 g of diacetyl per day (interquartile range [IQR] = 26278 g/day)

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Given the potential for confounding and limited causal inference derived from observational data, we used large, publicly available genome-wide association study (GWAS) data and two-sample MR methods to evaluate the relationships between substance use, substance use disorders (cannabis use disorder (CUD) and alcohol use disorder (AUD)) and respiratory infection and disease outcomes

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