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At the end of the 16th century, Sir Walter Raleigh, an English aristocrat, avid smoker, sailor and poet, established several tobacco plantations, including in the American territories

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Nicotine is known to be very addictive

61 The authors concluded that tobacco cessation is warranted in smokers with chronic obstructive pulmonary disease . 61 Smoking Damages Endothelial Cells The impact of smoking on cardiovascular disease remained controversial until the early 1960s, when the giant Framingham heart disease study showed smokings heart-related dangers

doi:10.1136/tc-2024-058817