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Following inhalation, carbon monoxide diffuses rapidly across the alveolar membrane and binds reversiblywith 240 times the affinity of oxygento divalent heme iron, forming carboxyhemoglobin (COHb)

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doi: 10.1211/PJ.2015.20069511 [2] Wills TA, Knight R, Williams RJ et al

A manual search of reference lists from identified published work and Google Scholar were also used to search for potentially eligible studies

The reason for this is that the number of smokers declined, smuggling increased, production costs increased, and ancillary wage costs increased