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The exclusion criteria included the use of other forms of tobacco, dual users (current, simultaneous use of conventional cigarettes and HTPs products), history of alcohol consumption, participants with a history of upper respiratory infections within the past three weeks, sinonasal disorders (nasal polyps, chronic rhinosinusitis, allergic rhinitis, severe septum deviation), a history of exposure to respiratory toxins other than cigarettes, malignancy, head trauma, neurologic, endocrine, and psychiatric disorders