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However, contrary to the decrease in procollagen I production when CSE was combined with SSL irradiation (3% CSE + 5 kJ/m 2 UVA, 3% CSE + 10 kJ/m 2 UVA and 3% CSE + 20 kJ/m 2 UVA), an increased procollagen synthesis tendency was observed when skin substitutes were only irradiated with 20 kJ/m 2 UVA (Fig

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