The shift in LC trends by histological type that occurred over the last several decades had been hypothesized to be due to changes in cigarette composition and design 31,32
Tar and Nicotine Content Hand-rolled cigarettes may contain varying amounts of tobacco compared to manufactured ones depending on packing technique, potentially affecting tar and nicotine exposure
She says this era of California culture brings to mind a similar period in the 1970s and 80s, when Americans started demanding more regulations for secondhand smoke, and a new etiquette around smoking took form
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