who brought tobacco to europe History of the emergence and development of the cigarette History of Tobacco: A Lucrative

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Environ Health Perspect 113(12):1795-801

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However, as the person becomes used to the effects of tobacco, these reasons for smoking tend to diminish as the alleviation of withdrawal symptoms such as low mood, irritability, poor concentration, restlessness and anxiety gain prominence (Benowitz Reference Benowitz, Hukkanen, Jacob, Henningfield, London and Pogun2010