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Effect of Nicotine on Immune System Function PMC Cigarette smoking weakens your immune system and increases your risk for respiratory infections. For free help to quit smoking visit CDC.gov quit. Smoking and Your Immune System Impacts of cigarette smoking on immune responsiveness: Up and down or upside down? PMC Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review Smoking cigarettes and commercial tobacco products use can weaken your immune system, making it harder for your body to fight off winter colds and illnesses. Protect yourself and your ability to fight

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