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Moreover, while smoking did not independently predict sex hormone-binding globulin (SHBG) levels, there was a positive association between increasing pack-years of smoking and SHBG levels [2]

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To the extent possible, current data on these metrics is included here for six major tobacco companies: Altria/Philip Morris, Philip Morris International (PMI), Reynolds American Inc

It has been shown that the increase in insulin resistance was halted after nicotine replacement was stopped, and even improved during continuous weight gain, [78] implying that nicotine rather than weight gain may be responsible for the initial increase in insulin resistance observed in some smoking-related studies

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