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While the precise mechanisms by which smoking increases cardiovascular disease are still being discovered, it has been shown to exert direct myocardial effects, such as increasing myocardial oxygen demand, lowering the threshold for angina, and Impairing exercise performance (Figure 2)

The FDA said it would develop a new batch of labels, but when new ones didnt appear, eight health groups sued the agency in 2016 for the unreasonable delay. Under a court order this year, the FDA was required to propose new labels by August, with final versions by next March

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