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I never expected such a dramatic impact." There was no guarantee that smoking rates would not start to rise again, after falling, and it was crucial to maintain the downward pressure, Professor West said

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[17] Since 2019, the smoking age in Minnesota was 21 under federal law

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Comprehensive genomic analyses have revealed a distinct tobacco-related mutational signature in liver tumors of smokers, characterized by cytosine-to-adenine base substitutions, dinucleotide alterations, and guanine adduct formation, patterns resembling those observed in lung and head-and-neck cancers [38,39,40]