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While there is evidence that these factors are independently associated with higher cigarette smoking prevalence, there are three important gaps in the literature: (1) mixed evidence regarding if these factors are associated with motivation to quit smoking and attempt to quit smoking, particularly for cannabis use, (2) evaluating the interaction between these three factors on quit motivation and quit attempts, and (3) cross-country comparisons based on varying regulatory environments, cultural norms, treatment/health care systems, inter alia

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In March 2018, the FDA again requested public comment on the role that menthol in tobacco products plays in attracting youth, in the likelihood of quitting smoking, and in the use of other tobacco products, including cigars and e-cigarettes