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Additionally, a recent longitudinal study of adolescents with ADHD suggested that treatment with stimulants (versus no treatment) reduces the risk for later smoking.[38] Of potential concern, though, laboratory studies among smokers without ADHD have shown that stimulant administration may acutely increase cigarette smoking,[39-41] potentially owing to a synergistic effect of stimulants and nicotine on mesocorticolimbic dopamine levels.[42-43] This concern may be tempered by evidence that bupropion, which has been consistently shown to be effective for smoking cessation, also acutely increases smoking rate in a laboratory setting.[39] Atomoxetine and bupropion, among other medications used in the treatment of ADHD, may hold appeal in the treatment of patients with co-morbid nicotine dependence

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