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A multinational RCT of more than 8,000 smokers found no significant increase in rates of moderate-to-severe neuropsychiatric adverse events with either varenicline or bupropion relative to nicotine patch or placebo in those with or without psychiatric disorders (although the trial excluded patients with symptomatically unstable psychiatric conditions) [57]

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In England, quite different from the rest of the world, e-cigarettes have been embraced by public health agencies as a tool to help people reduce the harm from smoking, says Jamie Hartmann-Boyce, PhD, assistant professor of health policy and promotion in the School of Public Health and Health Sciences

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