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In addition, providers sometimes prescribe second-line agents (clonidine and nortriptyline) for patients unable to use first-line medications

Overall, 42% reported using disposable e-cigarettes, 26% reported closed pod systems, and 26% reported open/refillable systems

Increasing Adoption of Synthetic Nicotine for Supply Assurance: Manufacturers are scaling synthetic nicotine facilities, leveraging chemical synthesis rather than extraction from tobacco

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