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For these reasons, I respectfully urge the Agency to incorporate illicit-market substitution effects into its evaluation of MRTP applications and to weigh whether timely authorization of qualifying products accompanied by appropriate post-market oversight may better advance the statutory goal of improving population health than continued regulatory limbo

To visualize the smoking-related traits prevalence/distribution by the ancestry PCs, we created a smoothed distribution of each individuals smoking phenotype using a radial kernel density estimate, as previously described 25

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There is good evidence of a relationship between smoking and CKD in patients with IgA nephropathy and kidney transplant recipients, but not in patients with DM or HT

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