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According to the Centers for Disease Control, cigarette smoking is directly responsible for more than 480,000 deaths per year in the United States

p = 0.79 and AUC 0120 min

"Tobacco: preventing uptake, promoting quitting and treating dependence"

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The findings were backed up by a report from the Australian government, which showed a similar drop in smoking prevalence - 0.55% - following the introduction of plain packaging there in 2012