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Furthermore, it was reported that short-term hookah use (both tobacco-based and tobacco-free products) disrupts the autonomic nervous system regulation on the cardiac cycle, thereby causing a reduction in HRvariability, whichin turnmight aggravate the risk of coronary artery disease development [18]

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Intravenous nicotine self-administration also allows for the precise quantification of the amount of nicotine infused by the animal (69), but there are translational limits with this approach as humans typically inhale most nicotine-containing products