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Compared with never-smokers, Inoue-Choi and colleagues identified risks for smoking-related cancers that were 2.16 (95% CI, 1.64-2.86) times higher in lifelong nondaily smokers, 3.65 (95% CI, 3.11-4.27) times higher in nondaily smokers who had previously been daily smokers and 4.88 (95% CI, 4.57-5.22) times higher in daily smokers

The first question acts to legitimize the methods implemented in the main analyses, while questions 2 and 3 serve to inform on the potential impact of ENDS policy actions

A positive association that is more evident in men

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Those symptoms can occur immediately or over a period of time

They are thus marketed by the tobacco industry as a healthier option