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Likewise, the geneenvironment interaction shapes individual variation in smoking behavior and nicotine dependence, but the publicly available NHANES does not have this information 26

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A well-documented case involved a coal worker producing black sputum due to anthracosis, where fibrosed lung tissue became cavitated by infection

By contrast, in the group of subjects who showed increased NNAL levels at some points during the smoking cessation program, the m 7 Gua and 8-OHdG levels did not coincide with the smoking cessation duration (Fig