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45, 46, 53 Tobacco smoke contains many substances that can activate DCs either directly or indirectly by triggering the release of danger signals and pro-inflammatory mediators from resident lung cells, which could be sensed by a wide range of DC-expressed receptors (Table 1)

Height: 2" = 5.20 cm Width : 0.95" = 24 mm

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However, for the millions of Canadians who continue to smoke, these taxes represent a substantial financial burden, particularly for lower-income households