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The latter is likely consuming a hefty dose of nicotine, which could lead to not only dependency but also increased risk factors for things like blood pressure spikes and oral health issues

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While the estimates of EC use should approximately apply to never-smoking adults, there is the possibility that including formerly and currently smoking adults in the model could bias the results toward the positive

Studies using NRT have confirmed that nicotine itself increases sympathetic nerve activity and elevates heart rate and blood pressure, effects that persist even during physiological stress like hypoxia (24)

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