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Understanding the mechanism of radiation induced fibrosis and therapy options

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38 Under the catalysis of LTC4S (leukotriene C4 [LTC4] synthase), which is a -glutamyltransferase and membrane-bound dipeptidase, leukotriene A4 can also produce a series of cysteine-containing leukotrienes (cysLTs), such as LTC4, leukotriene D4, and leukotriene E4

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Downregulation occurs through endocytosis

References Goldberg, T