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Despite numerous studies that prove the detrimental (and life-threatening) effects of smoking, millions of people across the world continue to pick up that stick and light it up

doi:10.1136/tobaccocontrol-2011-050345

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Therefore, we examined in first proof-of-principle studies whether pharmacological inhibition of the IL-1R/TLR-signaling associated IRAK4 kinase alleviates pulmonary inflammation and affects the recruitment of neutrophils and MoAM upon acute and sub-chronic smoke exposure ( Figure 8A )