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Where did they come from and more importantly how did they reach the level of pervasiveness that they currently occupy

Several reasons can be envisioned for this, including the possibility that individuals in group (i) may have more muscle mass or lean body mass, a gradual decline in U-Cr excretion with age [54] that may have occurred in group (ii), and the possible association between arsenic exposure and U-Cr concentrations (low U-Cr levels in groups ((iii), (iv)), as some studies have reported an association between As metabolism and the relative proportion of di-methyl arsenical species (DMAs) in urine with U-Cr [55,56,57,58]

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