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Of note, Cox2 can induce activation of oncogenic Kras leading to pancreatic inflammation and fibrosis, and development of pancreatic intraepithelial neoplasia lesions and pancreatic ductal adenocarcinoma (81)

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This hints at a possible shift in trade dynamics under the regional trade framework

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One drawback of this procedure was that only a square-wave puff profile was achievable rather than the bell-shaped puff profile, which is typically specified by standardised machine-smoking methods [12, 13] and also approximated by human smokers