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GERD occurs when acidic stomach contents reflux back into the esophagus, irritating its lining. Normally, the lower esophageal sphincter (LES) works like a one way valve, preventing this backflow. When this valve weakens 14 Surprising Facts About Heartburn and GERD Gastroesophageal reflux disease (GERD) definition and management Persistent Heartburn: When Lifestyle Changes Aren't Enough Cary Gastroenterology Associates What Causes Chronic Heartburn? Can smoking cause esophageal cancer? Roswell Park Comprehensive Cancer Center Buffalo, NY
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