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And the smoking ban was even years before that

However, no statistically significant associations were found between other participant characteristics and the psychological impact of nicotine pouch use (Supplementary file Table 1)

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doi: 10.1038/s41598-017-11779-9 154 ZhengL.ItzekA.ChenZ.KrethJ

The data required for the first three elements of the risk assessment process usually include in vitro and in vivo toxicology studies in animals, including dose-response studies