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Nicotine affects the cardiovascular system, and may pose harm to unborn fetuses, but it doesnt cause the chronic diseases associated with cigarette smoking

the heating element and the e-juice

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Muramoto ML, Leischow SJ, Sherrill D, et al

When the chemicals in cigarette smoke cause atherosclerosis and thickened blood in the arteries, it becomes more difficult for blood cells to move through arteries and other blood vessels to get to vital organs like the heart and brain

Inhaled nicotine rapidly reaches the brain, binding to specific receptors and triggering the release of dopaminea neurotransmitter linked to pleasure and reward