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However, high THC use may be connected to long-term negative psychiatric effects

Among children, serum LPS and zonulin were significantly elevated in both HTP- and cigarette-exposed groups compared with controls, showing no significant difference between exposure types

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Methods discussed in industry documents include price drops, increasing acceptance of smoking by nonsmokers, making products more socially acceptable, and making "healthier" cigarettes (scare quotes in original)

, dopamine, norepinepinephrine, acetylcholine, GABA and glutamate) in the reward/addiction pathways and involved in cognition, as well as activation of nicotinic receptors at the neuromuscular junction (Figure 2)

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