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p16 staining is negative Squamous Cell Hyperplasia Squamous cell hyperplasia is a descriptive term applicable, both clinically and histologically, to epithelial thickening of the vulva without identifiable causes or with difficulties in classification (hyperplastic dystrophy as old terminology) Localized pruritus is the most common presenting symptom Unilateral irregular white plaque-like lesions may be identified Nonspecific thickening of the vulvar epithelium is demonstrated by acanthosis with elongation, widening, and deepening of the rete ridges