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In the case of tobacco smoking, these active substances are a mixture of aerosol particles that include the pharmacologically active alkaloid nicotine, which stimulates the nicotinic acetylcholine receptors in the brain, and other non-psychoactive chemicals that result from combustion

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Several alkaloids, phenols, phenolic acids, and flavonoids found in tobacco and coffee have shown potent neuroprotective and anti-inflammatory activities in both in vitro and in vivo models of PD