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Culpeper went further saying, whoso useth more than four leaves shall be in danger to sleepe without waking. The plant was said to have special magical powers and was well known for its psychoactive properties, particularly in the Middle Ages when it was associated with witches brews and magic ointments

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In 1951 Theiler won the Nobel Prize in Physiology or Medicine for his work on the vaccine, becoming the first African-born Nobel laureate

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