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Such participants are often excluded from drug trials

Abbreviations BSA: Bovine serum albumin COPD: Chronic obstructive pulmonary disease CRD: Chronic respiratory disease CS: Cigarette smoke HCl: Hydrochloric acid HDM: House dust mite HNE: Human neutrophil elastase ICS: Inhaled corticosteroid ILDs: Interstitial lung diseases LPS: Lipopolysaccharide NF-B: Nuclear factor kappa B NLRP3: NOD-like receptor family pyrin domain containing 3 Nrf-2: Nuclear factor erythroid 2related factor 2 Keap-1: Kelch-like ECH-associated protein 1 OVA: Ovalbumin PM/PMs: Particulate matter PTEN: Phosphatase and tensin homolog TGF-: Transforming growth factor beta References Adcock IM, Mumby S (2016) Glucocorticoids

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