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Longitudinal studies are also needed to establish causal and temporal relationships between seizures and e-cigarette usage as users will be monitored over time to assess the incidence of seizures, to account for bias and confounding influences, and to take into account changes in e-cigarette use patterns or devices

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Smoking is the number one preventable cause of death worldwide, according to the U.S

27,28 Genetic polymorphisms in the genes responsible for ion channels, neurotransmitter receptors, and metabolic enzymes that are involved in the metabolism of nicotine and e-liquid may also affect the likelihood of developing seizures after using e-cigarettes