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The bottom line: effective cigarette smoke odor removal is a science, not a surface-level clean-up

We excluded some meta-analyses from Cochrane reviews (e.g., bupropion, NRT) because they included some RCTs with active controls, and we applied a strict placebo or usual care control criterion

Treatments come with the risk of side effects, such as pain, swelling, burning and scarring

Another interesting aspect of this study is the reported efficacy of glucocorticoids

Compare your options on WithPower Clinical Trials: Where Next-Gen Options Are Headed CYB003 (Deuterated Psilocybin Analog, Cybin Inc.) Mechanism: 5-HT2A receptor agonist (serotoninsame highway, different car) Results: 79% response rate at 3 weeks, no chronic sexual side effects, weight gain, or sedation NCT05385783 Osavampator (AMPA-PAM, Neurocrine) Mechanism: Enhances brain glutamate signaling (not serotonin) Results: Significant symptom reduction, low rates of sexual or metabolic side effects Phase 2 data Dextromethorphan-Bupropion (Auvelity) Mechanism: NMDA antagonist/sigma-1 agonist (plus NDRI) Results: Rapid effect (1 week), 54% response at 6 weeks, sexual dysfunction in only 2-3% GEMINI trial S47445 (AMPA-PAM, Servier) Mechanism: AMPA positive allosteric modulator Results: Favorable side effect profile (low sedation/sexual issues) Phase 2 data Trial participation: Typically free care/meds, lots of monitoring, sometimes a placebo arm