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Although early investigations have shown that antioxidant supplements had modulating effects on oxidative stress and AMS symptoms at high altitudes [94, 95], more recent studies indicate no effect [96,97,98] or mixed results [99]

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Bright light, exercise, and early caffeine all support it The problem is elevated cortisol late at night when the body is supposed to wind down Intense late evening exercise, stressful late night work, or a big meal close to bed all keep cortisol elevated past the point where it should be dropping

Regarding glutathione synthesis, its first step, the formation of -EC takes place in the chloroplasts and its transcriptional regulation by light intensity (higher expression under conditions of low light intensity than under normal light intensity) and far-red light (lower expression under white light with decreased red/far-red ratio) was shown in wheat (Gasperl et al

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