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Tobacco products contain additives to: make the smoking sensation taste or feel better (known as mouth feel) make the smoke less irritating to smokers mouths and throats, particularly to novice smokers increase the efficiency with which nicotine and artificial nicotine analogues reach the brain to maximise addiction regulate the burn temperature prevent the cigarette from going out when not being inhaled and to prevent the tobacco sparking and sending cinders onto smokers clothing reduce the smell of tobacco smoke retain optimum moisture in the tobacco (using compounds known as humectants) to stop tobacco drying out when stored or exposed to air

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In line with the principles of 21 st century toxicology, PMI is also developing novel in vitro methods for toxicity testing using human cells