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In addition, there is sufficient evidence of a causal relationship between tobacco smoking and an increased risk of cancer of the upper digestive tract, esophagus, stomach, bladder, kidney, colon, prostate, pancreas, and acute myeloid leukemia

This interaction can be disrupted when the cell detects DNA damage or other stresses, resulting in stabilization and activation of p53

There is a limited number of studies conducted in the higher pack-years ranges of smoking, and this is believed to be influenced significantly by the single study results from Schmidt 8 , which show a low OR on the dose-response curve

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